Showing posts with label Pediatrics. Show all posts
Showing posts with label Pediatrics. Show all posts

Thursday, 12 April 2018

FOANed Review #23

Salim Razie reviewed the Paediaric Acute Respiratory Interention Study (PARIS) on REBEL EM this week. The PARIS trial was an un-blinded, multi-center RCT that compared standard therapy to standard therapy with high flow nasal cannula (HFNC) in children less than one year of age with bronchiolitis. The results suggest that HFNC are a safe treatment option, and that infants treated with HFNC for bronchiolitis tended to have less escalations in care (transfer to ICU). The findings were even more pronounced in hospitals that didn't have access to pediatric ICU's - Good reading for anyone that looks after kids; great reading for those in rural or community settings where pediatric ICU admission means transfer.

http://rebelem.com/the-paris-trial-hfnc-in-infants-with-bronchiolitis/



There's a great case report by Jennifer Leckie and Minh Le Cong and Viran Kaul  that was published on prehospitalmed.com. It's a brief report of an Australian ICU nurse self administering nasal lidocaine to treat a cluster headache not relieved with her usual regimen of triptans, aspirin and acetaminophen. The nurse "snorted" a 5ml tube of 2% lidocaine (100mg), assumed the "Rose position" and allowed the gel to drip down her nasopharynx. The headache was completely resolved within 50 minutes of the treatment - This may not be applicable to your practice; but it's a fun read for all the self sufficient clinicians out there.




There was a post on EMCrit this week that reopens the FOAMed discussion on the "unopposed alpha phenomena". Unopposed alpha blockade is the premise that treating stimulant toxicity (specifically cocaine) with beta-blockers puts the patients at risk for a situation where the heart's (beta driven) contractility is blocked to the point where it can't overcome the afterload generated by peripheral vascular tone (alpha driven). The EMCrit post by Jeff Lapoint is in direct response to an older post by John Richards on LITFL. Jeff raises interesting questions about equivalency fallacies, and whether we should just because we could use beta-blockers for cocaine toxicity. That being said the original LITFL post still poses a valid question in asking if blanket avoidance of bet-blockers in stimulant toxicities is indeed dogma - Regardless of which camp you're in; both posts are well worth the read for anyone interested in toxicology. 


https://emcrit.org/toxhound/cocaine-beta-blockers-dogmalysis-wont-hunt/

https://lifeinthefastlane.com/beta-blockers-cocaine-stimulant-toxicity-time-retire-old-dogma-not-care/




Gus Garmel posted some true FOANed clickbait on ALIEM with: "10 Tips to improve patient satisfaction in the emergency department". Here's the overview:

        1. Greet everyone warmly
        2. Connect with everyone in the room
        3. Sit down if you can
        4. Listen actively
        5. Take your time
        6. Ask for their perspective
        7. Use at least one empathetic statement
        8. Check in with your patient
        9. Close the communication loop
        10. Show kindness & respect
- There's probably a lot here you do already, but it's nice to have it presented in a way that's easy to connect to - an easy read that's applicable to all clinicians.




Matt Douma offered up some experienced provider tips on ACLS at RescueScience. These tips and tricks are not intended for those new to, or attending their first ACLS class; rather it's further reading and the science behind the recommendations intended for those with ACLS "mastery". There are some good clinical pearls for maximising team dynamics: pre-charging the defibrillator, DSD pad placement, and how to cognitively offload the algorithm to focus on reversible causes - A great post for those comfortable with ACLS content and looking to augment whats taught on standard courses.


http://rescuescience.org/2018/04/11/advanced-life-support-course-2015-instructor-notes-for-aptil-10th-11th-class/




Friday, 21 August 2015

Weekly Review #14


Anaphylaxis is a fairly common presentation, in a previous post I reviewed Justin Morgenstern's (First10EM) post on the basics of managing these patients (Weekly Review #10). This week Brad Sobolewski's goes more in depth and discusses the evidence for using IM epi in anaphylaxis on Pediatric Emergency Medicine Blog (PEMBlog). While this post doesn't add a great to Morgenstern's general approach; it does add is a great review of the cornerstone of treatment: IM epi. Brad covers the typical dosing for adult and pediatric patients, the difference between SC and IM absorption rates, and epi's mechanism of action. He provides current evidence to support early epi administration, as well as his rationale for why you really can't go wrong in giving it. This is a succinct review, well worth a read either in conjunction with the post by EM in 10, or in isolation.

http://www.pemcincinnati.com/blog/why-we-do-what-we-do-epinephrine-in-anaphylaxis/




There was a video posted by Minh Le Cong on Pre-Hospital and Retrieval Medicine (PHARM) in response to a tweet made by Mike Abernethy. The video shows how to create PIP, and maintain PEEP using a high flow nasal cannula and occlusive dressing or bag. This is not something you will be likely to need in a metro center; but  I've worked in isolated and remote areas without access to Bi/CPAP, were techniques such as this could have been useful. If you find this video interesting I would suggest another video, posted by Scott Weingarton using high flow nasal cannula with a BVM. A good technique to know for nurses working in austere, isolated or remote areas.

http://prehospitalmed.com/2015/08/17/crashing-heart-failure-patient-no-cpap-no-problem-macgyver-it/




There was a post on Songs or Stories showcasing some tips and tricks for pediatric IV cannulation. Some of the fundamentals of good IV technique are covered here: correct preparation, position and anchoring. There are also some suggestions on anatomical references, the use of ultrasound, and a few others novel techniques that may be new to you. Worthwhile for all nurses as the tips can be used across patient populations.

http://songsorstories.com/2015/08/15/top-tricks-for-little-pricks/




In part 2 of his REBELCast Salim Rezaie discussed the effectiveness of using a length based tools, the Broslow Tape (BT), to estimate the weight of children. This was a review of a 2012 Canadian study that compared the actual weights of pediatric populations to their estimated weight using the BT. What they found was that on average weights were underestimated by ~7%. Even more importantly they found that 43.7% of patients had estimated weights 10% or greater different than their actual weight. This error in estimation could result in the under-dosing of patients in medication, electricity, and equipment size. Rezaie acknowledges that the BT is an estimation tool, that when used in an emergency or resuscitation situation will be accurate enough; however he does recommend getting a true weight on pediatric patients whenever possible. I would also suggest that the difference in weight also raises the concern of composition. As obesity will have an effect on not only total weight, but also ideal body weight, and total body water, which can have an impact of pharmacokinetics. There was a great review posted by Ian Miller from the Nurse Path (weekly review 8) that discusses these concerns from a nursing perspective in greater detail. The podcast by Salim Rezaie will be of interest to nurses working in pediatrics or emergency; the review from Ian Miller to all nurses.

http://rebelem.com/august-2015-rebelcast/



Justin Morgenstern discussed the management of life threatening asthma on First10EM. He starts with a review of the ABC's of care, provides a brief description of inhaled bronchodilators and the roll of epi.  The discussion about the definitive management of the airway and breathing is comprehensive, and this is where the post truly shines. He discusses why a conservative approach to airway management is warranted, offers suggestions for providing NIPPV, and discusses ventilator settings in the event the patient is intubated. There are great links to additional resources, as well as a summary of typical medications and dosages. Although there is little mention of the nursing role in managing these patients, I think it's still worth a read for emergency nurses: primarily for its review of ventilator settings.

http://first10em.com/2015/08/18/asthma/#more-661




I like the EM mindset series of posts on emDocs (Weekly Review #4). This week Daniel Cabrera had a post discussing "organizing chaos"; the triage process of identifying meaningful information using context, identifying priorities, and handling the fear of uncertainty. This is a post that will resonate beyond the emergency department walls, something that all care providers working in an overtaxed system can identify with.

http://www.emdocs.net/em-mindset-daniel-cabrera-the-chaos-organizer-and-the-fear-tamer/




PBS NewsHour ran a news story by Shefali Luthra about the difficulty of getting sleep in hospital. This is basically a discussion about the need for frequent checks on patients. I understand the sentiment of the author, who lamented their lack of sleep while admitted to the hospital, the loud and bright environment, and the frequent unnecessary interruptions to their sleep for routine care. As the person causing these interruptions to rest I acknowledge that there is a role for nurses to play in reducing them: by clustering care, being mindful to minimize noise, and in many cases by discussing with the responsible physician if the required frequency of assessment and medication administration is appropriate to the acuity of the patient.

http://www.pbs.org/newshour/updates/wont-hospitals-let-patients-sleep/#.VdNoMkXJE_A.twitter

Friday, 24 July 2015

Weekly Review #10


I listened to a podcast by Dr Jason Frank presented on the International Clinical Educator Network. The discussion reviewed an article on educational strategies to improve clinical reasoning. The article in question didn't discuss how they chose their strategies, or which strategies are most effective, so I don't think that the discussion can be appreciated in a meaningfully empirical manner. However there are strategies for teaching, and learning, covered in this podcast. The discuss focuses on 7 concepts of teaching:

Dual processing Model: The rapid interpretation of information through heuristics; and the slow analysis of novel information, with strategies to help learners switch between the two.
Conscious competence model: The movement from unconsciously incompetent to differing levels of competence. There is a great discussion about how peer learning, and how being able to remember being a new learner is a valuable tool for teachers.
Knowledge Organization: Different tools to structure knowledge of illness to typical presentations and the diagnoses.
Data Gathering and Data Processing: The use of standardized approaches and mnemonics to guide history taking and physical assessment, and how to filter through information to decide what information is pertinent to the clinical presentation.
Metacognition: Different ways to approach how you're reasoning through a clinical encounter.

This is a relatively quick podcast, the strategies for teaching are easily applied to learning. I think clinical reasoning is something that is continually perfected, and that there's something here for all learners.





There was a study published in the BMJ by Lyle Moncur et al., that examined the correlation between the socio-economic deprivation of a neighborhood in which a cardiac arrest occured and the rate of bystander initiated CPR. Moncur et al., did this by examining all OHCA registered with the North East Cardiac Arrest Network to determine how often bystander CPR was initiated, and the neighborhood in which the arrest occurred. The address was referenced to the Office of National Statistics to determine the level of socio-economic deprivation of the neighborhood (1 most deprived; 5 least deprived). The team was then able to compare the rates of bystander CPR by socio-economic neighborhood. 

There were 3862 OHCA calls screened for this study, 683 were excluded because of missing data. What the team determined is that as economic deprivation increase, rates of bystander CPR decrease: they found that CPR was initiated by a bystander nearly 40% as often when it occurred in an affluent neighborhood. These results are sad, but they`re certainly not new. Similar studies were performed in the US and Asia, showing similar results: as poverty increases bystander CPR decreases, they also cited differences in racial composition of neighbourhoods as a possible factor for differences in rates of bystander CPR. This study however was performed in an ethnically homogeneous region (>95% white), on a homogeneous patient population (96% white); and as such they're able to exclude race as a confounding factor. The study doesn't attempt to explain why this relationship occurs, although lack of access to training was cited as a potential cause. From a nursing perspective this will likely not impact in-hospital care of poor patients; but it may suggest that targeting CPR education to poor neighborhoods could be an effective public health mandate. 





Justin Morgenstern from First10EM posted a review of managing patients with anaphylaxis. He starts with the obligatory cry of "give the IM Epi stat!": something that still takes on average way too long. Morgenstern then discusses some possible approaches to  manage both difficult airways, as well as patients with developing angioedema. There is a good review of shock, with some links to push dose mixing charts, management tips for special populations and a "Dirty Epi Drip" set up. This is a great review for nurses, as Morgenstern makes suggestions not only on medical practice; but also on priorities of care for nursing. Great to see FOAMed that includes the whole care team!




Dr. Rebecca Schroll et al., published a study in the Journal of Trauma Acute Care Surgery earlier this year that compared the outcomes of military and civilian patients who were treated with tourniquets by pre-hospital providers for extremity trauma. This study retrospectively examined the records of patients treated with pre-hospital tourniquets from 9 level one trauma centers in the US and compared them to a prospective military study examining patients treated pre-hospitally with tourniquets during the Iraq war.

Schroll et al., reviewed the charts of patients meeting inclusion criteria (>18 years old with extremity trauma treated by tourniquet) and examined them for mortality, effectiveness of tourniquet at controlling  hemorrhage, change in SBP after tourniquet application, and complication rates. 197 patients met the inclusion criteria; the average patient was a 39.4(±1.1) year old male (85.8%) with a penetrating injury (56.3%) and ISS of 11. Tourniquets were successful for controlling hemorrhage 88.8% of the time, the overall mortality rate was 3.0%, the average complication rate was 32.4%, with 18.3% of patients requiring amputation.

The results were then compared to a seminal study of combat application tourniquets in Iraq performed by Kragh et al., in 2009, to determine how civilian tourniquet use compared to military use. Schroll et al., determined that the use of tourniquets in the civilian context tended to have better outcomes than the group from the Iraq war study; with both mortality (3 vs. 11%), and amputation rates (18.8 vs 41.8%) being lower. These are impressive statistics, and would seem to suggest that tourniquet use for extremity trauma is safe. They're especially impressive considering that 20% of the patients in the Schroll et al., review were treated with improvised tourniquets that were either self or bystander applied, with "no difference in the incidence of other complications".

There are however a few claims made by the authors that I think are overstating the level of this evidence. The study design is weak: there was no control arm to compare outcomes against, there was no discussion on which commercial tourniquets were used, or the indications for using them. The patients in this cohort have drastically different mechanisms from the military cohort; all of whom had blast injuries, tended to be more severely injured, and were being treated in an austere environment (compared to a level one trauma center). The military cohort is also missing key information about limb injury severity and time to "definitive" care, limiting the extent to which the groups can be compared. The claim that improvised tourniquet use had comparable results with no difference in complication rates is also questionable. The that total tourniquet time for this subgroup is unknown, and that the group treated with non-purposed tourniquets had a three fold rate of ischemic/reperfusion injuries (3/40 [7.5%] vs. 4/157 [2.5%]). The suggestion that improvised tourniquets were safe and effective is contrary to previous observational studies that noted higher error rates, and the need for tightening or application of commercial tourniquets when improvised tourniquets were used (see weekly review 1).

I think this research is important, it's the largest of it's type in the civilian context, and in general I think that the evidence supports the use of tourniquets in the civilian context. I don't think that the patient populations were homogeneous enough for this research to be used as a comparison to the Baghdad study by Kragh et al., and would not attempt to extrapolate their findings to the civilian context. I would also disagree with the claim that improvised tourniquets are safe and effective, there were too few patients recruited to make that claim and the outcomes (though underpowered) actually show a three fold increase in risk.

From a nursing perspective I think that this is weak evidence showing that tourniquets are safe for extremity trauma in general. It also shows that a large number of patients will present with improvised tourniquets, and these will need to be assessed as venous only tourniquet can actually speed exsanguination.

http://www.ncbi.nlm.nih.gov/pubmed/26091308





Dr. Geoff Jara-Almonte posted a review of neonatal resuscitation on emDocs this week. He touched on the major steps and take home messages you could expect to learn from an NRP course. The post discusses some of the controversy around the need to intubate, the when and hows of meconium suctioning, and the FiO2 that should be used during resuscitation. There is a quick review of resuscitation drugs and doses, as well as methods for gaining vascular access (umbilical cannulation). This is a great review for any nurse working in the ED, it certainly won't replace an NRP course nothing will replace real time simulations using the kit; but it's a succinct review of the need to know points of neonatal resuscitation.

http://www.emdocs.net/neonatal-resuscitation/ 

Monday, 8 June 2015

Weekly Review #5


A group of Chinese researchers compared silver sulfadiazine (Flamazine) to Mepilex Ag for treatment of deep partial thickness burns. This was a multi-center, open, parallel, randomized comparative study of patients with thermal burns to 2.5-25% TBSA (<10% TBSA third degree). Exclusion criteria were burns >36hrs from enrollment, infection, skin disorders, certain medical and immunological conditions, and immunomodulating medications. Primary outcome measure was time to healing; secondary measures were: percentage burn healed per visit, number of dressing changes, and number of burns requiring grafting. Nurse investigators performed debridement on day zero and as required, assessed wounds, performed dressing changes, while noting ease of dressing change and wound-dressing adherence. Patients in the Mepilex Ag had dressing change every 5-7 days depending on need, patients with SSD dressing had daily dressing changes. Patients were asked to report on anxiety of dressing change, pain of dressing change, and comfort of dressing during daily living.  153 patient met inclusion criteria 46% were assigned to Mepilex Ag. Average patient age was 36.2 yrs, 27% were female, all were Asian, all other baseline characteristics between the groups were similar. Between the two groups: healing times 16.2 (Mepilaex Ag) vs 17.0 days (SSD), and rates of successful healing (79%) were similar, additionally there was no difference in graft rates or total burn area healed by the ends of weeks 3-4. Mepilex Ag had higher patient satisfaction for comfort, anxiety, and pain of dressing change with pain and anxiety scores tending to be about half of the SSD group scores. There were fewer dressing changes required in the Mepilex Ag arm, and higher ratings by nurses for ease of application. There were more patients in the Mepilex Ag arm healed by week 2 (day 7), more patients in the SSD group who developed new infection of the burn (9 vs 6%), and more patients in the Mepilex Ag arm who required subsequent wound debridement: although this is likely due to lower rates of wound-dressing adhesion . These findings support previous studies of similar design, and suggest that there may be an opportunity for cost savings due to decreased material and labour costs. From a nursing perspective this research suggests that following standard practice of Flamazine and non-stick dressing, may not be to the benefit of the patient, provider or health care system.
http://journals.lww.com/jtrauma/Abstract/2015/05000/An_open,_parallel,_randomized,_comparative,.16.asp

Ian Miller from the Nurse Path posted a link on his twitter feed this week to NPS MedicineWise Education modules. These are free continuing education modules designed for physicians, pharmacists, and nurses. There is a broad selection of modules: case studies, medication reviews, laboratory test reviews, even modules on how to improve charting. These modules will count toward continuing education credits among Australian professional bodies, and offer free access to education materials for clinicians from other countries, worth a look. 
http://www.nps.org.au/health-professionals/cpd/nurses




I was doing some research on triage and came across a 2012 article published in the Journal of Internal and Emergency Medicine that looked interesting. It was a before/after single center intervention to determine if a physician in triage would increase ED patient throughput. Secondary measures were length of stay, time to attending physician assessment, time to disposition, number of patient who left without being seen, and time on ambulance diversion. ED patient encounters during the 3 months preceding the intervention were retrieved from an electronic record database, and used as the control arm. During the study period one additional physician was added to triage, and one RN and ED technician were reassigned from other areas within the ED to the physician triage team daily from the hours of 1300-2100 for three months. This triage team would then order labs and diagnostics, administer medication, fluids and other treatments, after which the patient would move to another area of the department to be assessed by the attending physician. The physician in triage (PIT) would also supervise the physician assistant (PA) in the fast-track area, answer calls from referring physicians, and engage in administrative roles when not engaged in triage activities; the authors didn't specify what the RN or ED technician did during these periods. During the study period 17,631 patients met the inclusion criteria, 9,218 in the intervention group. The PIT evaluated an average of 37.8 patients per 8-hour period (15.1 seen and discharged with the PA, 4.9 seen and discharged as sole provider in fast-track, and 17.8 triaged to be seen by another attending physician). During the intervention period time to assessment by attending was reduced by 36 minutes (1:41-1:05); Length of stay (LOS) was reduced by 12 minutes (3:51-3:39). LOS and time to assessment were also decreased during the study period during the times the PIT was not present. The percentage of patients who left without being seen saw an insignificant decrease (1.47-1.33%), and the time spent on diversion decreased significantly during the intervention period (3.1-1.2%). While a PIT model is exciting there are a few shortcomings in this research: the intervention was the addition of a staff physician for 8 hrs a day (two full time physicians per year). Because there was an addition of extra staff there's little surprise that time measures were decreased, what wasn't assessed however was if there was any change in clinical outcomes. Unfortunately this study design doesn't provide any insight into what part of the intervention resulted in increased throughput: was it more staffing, faster initiation of diagnostics, or an integrated model of Physician/RN/ED Technician that resulted in faster access to care. From a nursing perspective this is exciting research, but it fails to reveal what the true cause of increased ED throughput was, and if it was clinically significant.
http://link.springer.com/article/10.1007%2Fs11739-012-0839-0

Charlotte Davis from Paediatric Emergency Medicine put together a nice blog post on functional pediatric abdominal pain. Functional abdominal pain (pain with no identifiable medical cause), she suggests, could be responsible for as much as 25% of pediatric abdominal pain Davies has a a brief write up on some possible causes for this type of pain: duodenal ulcer, irritable bowel syndrome, and abdominal migraines. She also offers some suggestions for clinical work-ups,  and red-flag findings. From a nursing perspective there is some insight to be gained from causes of pediatric abdominal pain, the red-flag findings may also be helpful for stratifying risk with pediatric populations during care or triage. 
http://paediatricem.blogspot.ca/2015/06/functional-abdominal-pain.html

BioMed Research International (a free open access journal) published some research on the effects of IV fluid volumes on mortality. The study by Hussmann et al., was a retrospective examination of the relationship between pre-hospital IV fluid replacement and mortality of patients from a German trauma registry. 7461 patients met inclusion criteria (admitted patients, age ≥16, ISS ≥16), and were cohorted into 5 groups according to total pre-hospital IV fluid received: (0-500mL, 501-1000mL. 1001-1500mL, 1501-2000mL, >2000mL). Multivariate mortality analyses were performed by: volume replacement, age, trauma score, type of trauma, pre-hospital interventions (chest tube/ETT insertion, pressor usage), and lab parameters (HgB, BE, PTT). They determined that there was a correlation between volume of fluid administered and overall mortality. However there are some aspects of the design and statistical findings that may limit it's usefulness to practice. All of the patients in this study were physician attended pre-hospital, which does not generalize to all EMS systems. As volume of fluids administered increased so too did injury severity, number of interventions performed and injury severity. It it likely that IV fluid administration not the causal factor in this correlation; rather, as severity of injury increased so too did the number of interventions performed, the time required to perform these interventions would increase, and therefore the period of time in which to administer fluid would increase, hence an increase in overall volume. Likely injury severity is causal factor in the outcome/ volume administered relationship. Unfortunately there are no The findings are hard to interpret as there was no specifics on average total volume administered per volume quintile, so it's possible that the majority of patients where clustered around cut-off points. Finally the statistical findings are not terribly convincing, as the majority of the confidence intervals for mortality odds ratios cross one in the general population. It is only the post hoc analysis for non-head injured patients that there is any statistical significance of increased risk associated with volume; however this may still not be clinically significant as it is more likely a result of increase in injury severity and patient acuity than an independent risk factor. From a nursing perspective this research has little to add, although the results are of questionable use it is a reminder that IV fluids should not be considered benign. 
https://www.readbyqxmd.com/read/25949995/prehospital-volume-therapy-as-an-independent-risk-factor-after-trauma#.VV4fMVQNHz0.mailto